Pro-metastatic intracellular signaling of the elaidic trans fatty acid

Fatty Acid Signaling: The New Function of Intracellular Lipases

Until recently, intracellular triacylglycerols (TAG) stored in the form of cytoplasmic lipid droplets have been considered to be only passive "energy conserves". Nevertheless, degradation of TAG gives rise to a pleiotropic spectrum of bioactive intermediates, which may function as potent co-factors of transcription factors or enzymes and contribute to the regulation of numerous cellular process...

Isomerization of stable isotopically labeled elaidic acid to cis and trans monoenes by ruminal microbes.

A previous study showed that oleic acid was converted by mixed ruminal microbes to stearic acid and also converted to a multitude of trans octadecenoic acid isomers. This study traced the metabolism of one of these trans C18:1 isomers upon its incubation with mixed ruminal microbes. Unlabeled and labeled (18-[13C]trans-9 C18:1) elaidic acid were each added to four in vitro batch cultures with t...

Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study

BACKGROUND Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition (EPI...

All-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway

Omega-3 and Trans Fatty Acid Interactions

For those who do not consume preformed DHA from dietary sources, concern has been expressed about the potential inhibitory effect of high trans fatty acid (TFA) intakes in the diet relative to ALA and the potential for an even more compromised conversion efficiency from ALA to DHA. This concern is based on extensive literature indicating that high trans intakes in experimental animals partially...